Bacteriological and pathological studies were carried out on 500 animals (336 cows and 164 buffaloes) slaughtered in two abattoirs at Is­mailia Governorate, Egypt. From these animals 1500 proper samples were taken from small intestine, mesenteric lymph nodes and liver. The bacteriological examinations of these organs revealed that the total av­erage percent of enteric bacterial isolates in cows was 66.6% and in buf­faloes was 59.1%. The bacterial isolates were identified as E. coli, Salmo­nella, Enterobacter, Proteus, Klebsiella, Citrobacter, Yersenia and Edwardsiella. The percentage of these infections varied in both cows and buffaloes. The isolated Salmonella spp. were identified as Salmonella en­teritidis and S. cerro with a percentage of infection in cows 13.98% and 7.47%, while, in buffaloes it was 10.4% and 3.65%, respectively. Salmo­nella enteritidis phage type 4 was diagnosed in both cows and buffalo Salmonella. Most of the enteric isolates did not influence the gross and histological structure of the examined organs. However, in E.coli, Salmo­nella spp. and Yersinia infections, the pathological changes in intestine, mesenteric lymph nodes and liver were pronounced and differed in their severity according to the type of infection. These changes were illustrat­ed and discussed.