Graded doses of vit. E (30, 60, 100 ppm) were fed to one-week­old commercial balady native strains broiler chicks for one month. Re­sults indicated improvement in blood profile. Biochemical analysis at mega dose revealed significant increase of serum cholesterol, aspartate amino-transferase (AST), alanine amino-transferase (ALT), urea and creatinine. Protein electrophorosis indicated hyperproteinaemia and hyp­er 13 and y globulinaemia at 60 ppm dose (immunostimulant), while, mega dose 100 ppm lead to hypoproteinaemia and hypo p and y globulenae­mit. It was concluded that mega dose of vit E at 100 ppm was asso­ciated with biochemical hepato-nephrotoxic disorders in broiler chicks, while at suitable dose of vit. E revealed an immunostimulant effect and improved blood profile.