Five Nile fishes namely Oreochromis niloticus, Saris based Syn­odontis (Schell or niloticus), Clans Were and Mugil cephalus were col­lected from fish resources in Giza Govemorate. Samples from each were weighed and muscles were digested and analyzed for lead, cadmium, copper and zinc. The levels of Pb residues were 0.02, 0.03, 0.02, 0.06 and 0.14 ppm in Oreochromis niloticus, a bayed, Synodontis sp., Cl. !az­Ma and Mugil cephalus, respectively. The levels of Cd residues were 0.10, 0.13, 0.18, 0.24 and 0.29 ppm, in Oreochromis niloticus, EC bay-ad, Synodontis sp., Cl. lazera and Mugil cephalus, respectively. The levels of Cu residues were 0.04, 0.06, 0.03, 0.03 and 0.03 ppm, in Oreochro­MIS niloticus, a bayed^, Synodontis sp., Cl. lazera and Mugil cephalus, re­spectively. The levels of Zn residues were 0.22, 0.42, 0.16, 0.27 and 0.75 ppm in Oreochromis niloticus, B bayed, Synodontis sp., Cl. lazera and Mugil cephalus, respectively. The results indicated an Increased bio­accumulation of heavy metals in aeries Were sp. and Mugil cephalus sp with lead and cadmium compared with other three species, in addition to zinc in Mugil sp. The results are discussed with other previous reports and their hazardous health effects.