Susceptibility of two strains of the two-spotted spider mite to different pesticides was investigated. The results revealed that Kafr El-Sheikh and EI-Gharbiya field strains showed different degrees between vigor tolerance to some compounds such as commite and kelthan with RR 6.33, 5.83, 3.39 and 3.21 folds to susceptibility such as micronized sulphur and volck oil. For kelthan, it appears that adding volck oil de­creased Lcso value from 190 to 140ppm, while adding ridomil decreased Lc50 from 190 to 150ppm for Kafr El-Sheikh strain, while no changes were happened for EI-Gharbiya strain. Volck oil caused inhibition to corn-mite by increasing its Leto from 760 to 800 and from 700 to 720ppm for Kafr EI-Sheikh and El-Gharbiya strains. On the other hand, ridomil showed reverse effect for Kafr EI-Sheikh and demonstrates nil effect for EI-Gharbiya strain. Combination between cymbush and volck oil combined effect became more strong; the Lc50 was decreased from 110 to 90 and from 115 to 9Oppm for Kafr El-Sheikh and EI-Gharbiya field strains. The combined effect of volck oil and kindo was extremely low and the corresponding Leto was decreased from 55.00 to 54.00 and from 50 to 43ppm for Kafr EI-Sheikh and EI-Gharbiya strains. The Lc50 values were decreased from 230 to 210 and 270 ppm for both volck oil and ridomil when mixed together with marshal, for Kafr Et-Sheikh. When adding volck oil or ridomil to micronized sulphur Lc50 was increased from 7000ppm to 16000 and 13000ppm and from 9000 to 17500 and 10000ppm for Kafr EI-Sheikh and EI-Gharbiya strains, respectively.