A field study was conducted at Rice Department Experimental Farm, Sakha Agricultural Research Station, ARC, Egypt during 2020 and 2021 summer seasons, to investigate the best chemical weed control treatment of direct seeded-rice on furrows as innovative method under different irrigation intervals. A strip plot design with three replications was used. Irrigation intervals every 4 (I1), 8 (I2) and 12 days (I3) were assigned in horizontal plots and six weed control treatments were allocated in the vertical plots which contained (W1): Saturn 50% EC (thiobencarb) at 3.57 kg ai ha-1 at 4 days after seeding (DAS), (W2): Stomp 50% EC (pendimethalin) at 2.023 kg ai ha-1 at 4 DAS. (W3): Saturn followed by Repair 18% TB as a ready-made of quinclorac 16.5% + bensulfuron-methyl 1.5% at rate of 0.491 + 0.0446 kg ai ha-1 at 25 DAS. (W4): Stomp followed by Repair 18% at 0.536 kg ai ha-1 (W5): weed free and weedy check (W6). The obtained results showed that I1 treatment exceeded the other irrigation intervals and recorded the lowest dry weights of grassy weeds as well as total weeds, in spite of gave the highest dry weights of broad leaf weed, in addition to the highest rice dry weight, grain yield and its attributes in the two seasons.