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298972

PRODUCTION AND EVALUATION OF A NEWLY ADJUVANTED RABBIT PASTEURELLOSIS VACCINE

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Last updated: 24 Dec 2024

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Abstract

Rabbit pasteurellosis aluminium hydroxide gel adjuvanted vaccine (ALV) and aqueous formalized one (AV) were evaluated serologically and by 2-stage protection bioassay. Evaluation in mice revealed a good pro­tection level (85%) in either ALV or AV vaccinates, when subjected to homogenous challenge exposure. In rabbits, both vaccines stimulated satisfactory and significantly differed antibody levels. However, level re­corded in ALV vaccinates persisted for more prolonged period (16th week post-boostering, PB) than in case of AV. Moreover, sera from rab­bits immunized with ALV or AV form passively protected mice at a levels of 70% and 60%, respectively. The let-stage bioassay conducted at ri weeks PB revealed no difference in the level of protective immunity (80%) between rabbits vaccinated with either forms of vaccines. However, the 2m-stage bioas­say conducted at 16th week PB revealed a superior protective level (70%) in ALV vaccinates versus 50% only in AV ones. The ALV-based Pasteur°Ua vaccine proved to be safe and effec­tive alternative to the classical aqueous one for controlling P. multocida infection in rabbits.

DOI

10.21608/ejar.2003.298972

Authors

First Name

AHMED M.

Last Name

DAOUD

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Affiliation

Veterinary Serum and Vaccine Research Institute, Agricultural Research Center, Ministry of Agriculture, Dokki, Giza, Egypt

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First Name

MANAL S.

Last Name

MAHMOUD

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Affiliation

Veterinary Serum and Vaccine Research Institute, Agricultural Research Center, Ministry of Agriculture, Dokki, Giza, Egypt

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First Name

HALA A.

Last Name

FADL

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-

Affiliation

Veterinary Serum and Vaccine Research Institute, Agricultural Research Center, Ministry of Agriculture, Dokki, Giza, Egypt

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Orcid

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First Name

ELHAM A.

Last Name

YOUSSEF

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-

Affiliation

Veterinary Serum and Vaccine Research Institute, Agricultural Research Center, Ministry of Agriculture, Dokki, Giza, Egypt

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Orcid

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First Name

HASSAN A.

Last Name

HASSAN

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-

Affiliation

Veterinary Serum and Vaccine Research Institute, Agricultural Research Center, Ministry of Agriculture, Dokki, Giza, Egypt

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Volume

81

Article Issue

4

Related Issue

39839

Issue Date

2003-12-01

Receive Date

2003-07-12

Publish Date

2003-12-01

Page Start

1,905

Page End

1,917

Print ISSN

1110-6336

Online ISSN

2812-4936

Link

https://ejar.journals.ekb.eg/article_298972.html

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https://ejar.journals.ekb.eg/service?article_code=298972

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28

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Original Article

Type Code

1,041

Publication Type

Journal

Publication Title

Egyptian Journal of Agricultural Research

Publication Link

https://ejar.journals.ekb.eg/

MainTitle

PRODUCTION AND EVALUATION OF A NEWLY ADJUVANTED RABBIT PASTEURELLOSIS VACCINE

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Article

Created At

24 Dec 2024