The present study was conducted to detect and determine albu­min, transferrin and Hi loci and their relation with egg production trails and body weight of Japanese quail . A total of 305 Japanese quails pro­duced during twelve hatches from twenty-one sire families were used in the present study. Individual body weights were recorded at different ages. Egg production traits were egg number, egg weight and egg com­ponent weights. The analysis detecting for the three loci was practiced on the whole blood for Hi gene and in plasma for albumin and transfenin loci. Results showed that albumin locus had only two genotypes , the dominant homozygote (AIAI) has higher egg number (88 eggs), while, (Alai) genotype showed seven days earlier in sexual maturity. Transferrin locus showed that (TfTf) genotype recorded the higher egg number (89 eggs) and earlier sexual maturity with five days. Moreover, Hi locus had no clear effect on all the characters studied.