An experiment was conducted to study the effect of using black seed (BS), dried garlic (DG) and onion (DO) powder at level of 1% each on physiological parameters and reproductive performance. A total of 32 New-Zealand White (NZW) rabbits does were distributed into 4 treat­ments (8 rabbits each). The diets were formulated to be iso-nitrogenous (17% CP) and iso-energetic (2700 Kcal DE/Kg diet). The dietary treat­ments were fed to rabbits for two parities. The results showed that Ht, Hb.1³4. GOT. CPT. Alb, Glb, A/G ratio, T3, RBCs, TP and WBCs counts were significantly improved by adding of either black seed, garlic or onion to rabbit diets. Also, there was an im­provement in all parameters studied, especially those related to repro­ductive performance, and marked reduction in total lipids and cholesterol values were obtained due to BS, DG and DO supplementation as com­pared to the control group. The second parity showed a slight improve­ment in all parameters studied as compared to the first one. It can be concluded that supplementation of BS, DG and DO showed a significant role in enhancing the immune system, and reproduction due to their con­tents from active principles belonging to each of them.