to reduce agricultural water use. A field experiment was carried out at EL-Bostan Agricultural Farm, Faculty of Agriculture, Damanhur University, EL-Behira Governorate, Egypt, during two successive summer seasons 2020 and 2021 to investigate the effect of foliar application of potassium, silicon, and selenium on some growth characteristics, chemical properties, yield, and some related traits of the peanut crop (Arachis hypogea L.) under water deficit conditions. A split-plot design was used; three depletion ratios (50, 60, and 70%) of available water were applied in the main plots, while four spray treatments (tap water (as control), 2% K2SO4, 2 mM Si as Na2O3Si.9H2O, and 30 g Se/ha as Na2SeO4) were laid in the subplots. The findings revealed that increasing the depletion percentage from 50% to 70% resulted in a significant decrease in all traits except the shelling percentage. Potassium foliar application produced the highest plant height and the number of branches per plant, whereas silicon treatment resulted in the highest pod yield per plant, seed yield per plant, shelling percentage, 100-pod weight, 100-seed weight, and pod yield. Treatment with selenium led to high chlorophyll contents. The interaction between the two studied factors showed that irrigation after a 50% depletion ratio with potassium foliar application recorded significant values of the plant height and number of branches. The highest content of chlorophyll was achieved when the crop was treated with selenium under irrigation after depleting 70% of the available soil moisture content. The highest values of pod yield per plant, seed yield per plant, and pod yield (ard/fed) were observed when the peanut was irrigated after a 50% depletion ratio with silicon foliar application. The best shelling percentage was achieved with potassium under a 70% depletion ratio. The treatment with silicon under a 60% depletion ratio recorded the heaviest 100-pod weight and 100-seed weight. When peanut plants are subjected to water stress, treatment with silicon, potassium, or selenium reduces crop losses and increases plant tolerance to stressful water conditions.