Background: Knee bursitis worsens over time leading to severe physical disabilities, and psychological disturbance. Strengthening exercises provide a promise in improving functional capacities and quality of life of the patients. Aim: to assess the effect of knee strengthening exercises on quality of life among patients with knee bursitis. Research design: Pre-experimental research design one group pre\post test methods. Research Setting: The research was applied in orthopedic department at Assiut University hospital. Research sample: A purposive sample of 60 patients of both sexes their ages from 20 to 65 years old. Tools: (I): Patient's assessment sheet (demographic & medical data), (II): Modified Cincinnati Rating System Questionnaire and (III): The Knee Quality of Life (KQoL-26). Results: There were statistically significant correlation between quality of life and physical status after 2 months after application of knee strengthening exercises also between educational levels and both physical functioning and activity limitations (0.001 and 0.009). There was a positive correlation between total scores of both modified Cincinnati rating system and the knee quality of life (KQoL-26) (P.0.001, r. 0.712). Conclusion: Application of knee strengthening exercises resulted in significant improvement in the physical status with greater increase in the studied patients' quality of life. Recommendations: Regular program's training to maintain the nurses in orthopedic department updated with research-based techniques and an array of interventions for decreasing patients' disabilities and increase the quality of life.