Background: Premenstrual syndrome (PMS) significantly affects the daily lives of young females. Mindfulness training can empower them by providing practical techniques to manage PMS symptoms effectively, potentially reducing their reliance on medication. This study aimed to examine the effect of mindfulness training on premenstrual syndrome among young females. Study Design: A quasi-experimental one-group pre-post-test design was adopted. Study Setting: The Gynecological Outpatient Clinic of Sohag University Hospital, Sohag Governorate, Egypt. Study Subjects: A convenient sample of 84 young females was recruited. Study Tools: Three tools were used for data collection: a structured interview questionnaire, a modified premenstrual syndrome screening tool, and a five-factor mindfulness questionnaire. Results: Mindfulness training significantly reduced the total physical, behavioral, and psychological symptoms of PMS as compared to pre-intervention (45.6±9.4 vs. 77.1±9.6, respectively). Moreover, the mindfulness mean score increased significantly from pre- to post-intervention (130.9±9.3 vs. 169.6±16.5, respectively). Conclusion: Young females who engaged in mindfulness training demonstrated improvements in their physical, behavioral, and psychological symptoms associated with premenstrual syndrome, alongside an increase in their mindfulness scores. Recommendation: A mindfulness training was effective in managing, alleviating the symptoms and intensity of premenstrual syndrome. Mindfulness training program may be used as a therapy for premenstrual syndrome. Future studies should test MBSR in larger and more diverse groups of women with premenstrual syndrome.