Background: Children with traumatic brain injuries need specialized care, so their mothers must be provided with adequate information required to give this care. Using family-centered care in practice supports families, particularly mothers and involves them in the care of their children. The present study aimed: To evaluate the effect of family centered care intervention on coping patterns of mothers and participation in caring for their children with traumatic brain injury. Subject & Methods: A quasi- experimental study was conducted on 50 mothers whose children had traumatic brain injury at Accidental Hospital's Neuro-Surgical Department in Zagazig University Hospitals. Tools: Five tools were used as follows: Mothers and children socio-demographic data, Family-Centered Care Scale, Index of Parent Participation, Mothers' Reported Practice Checklist and Coping Orientation to Problems Experienced Inventory Scale. Results:  Nearly three-quarters of the studied mothers provided moderate participation in activities of care for their children before the intervention that improved to a maximum participation among all of them post the intervention. More than half of mothers demonstrated low coping patterns pre-test, compared to the majority of them showed a higher coping post-test. Furthermore, there were highly statistically significant differences between the total studied mothers' coping patterns & their participation mean scores pre/ post-test (P≤0.001). Conclusions: The family-centered care intervention had a significant effect on enhancing mothers' coping patterns and participation in the care of their children with traumatic brain injury. Recommendations: Designing and implementing educational programs for pediatric nurses to promote family centered care in clinical practice.