Background: A proactive personality enables students to overcome environmental constraints and move faster towards identifying opportunities, then developing positive improvisations as a critical strategy for dealing with emergencies and risks in the entrepreneur process. Aim: Investigate proactive personality and entrepreneurial intention among internship nursing students and individual improvisation as a mediating role. Design: A descriptive, correlational, and comparative research design was used. Setting: The research was conducted at the Faculty of Nursing, Menoufia University, Menoufia governorate. Subjects: Included a convenience sample of internship nursing students during the academic year 2022/2023(n= 408). Instruments: Three instruments were used; (1) proactive personality scale, (2) Entrepreneurial Intention Questionnaire, (3) individual improvisation behavior scale. Results: Nearly half (48.5%) of studied internship nursing students had a high level of proactive personality while more than half (59.8%) and more than two-thirds of them (67.4%) had a moderate level of entrepreneurial intention and individual improvisation, respectively. Also, a highly positive significant correlation was observed between proactive personality and both entrepreneurial intention and individual improvisation among internship nursing students (p-value <0.0001). Conclusion: The results collectively indicated that individual improvisation has a mediating role in the relationship between proactive personality and entrepreneurial intention. Recommendations: Pay attention to the proactive personality traits among nursing students by academic nursing institutions to develop strategies for recruiting those with such traits and engaging them in experiential learning projects that necessitate hands-on fieldwork and operational research. Fostering entrepreneurial culture can be revealed through co-curricular. Additionally, consider improvisation techniques as basic nursing skills that need to be practiced in undergraduate courses.