Background: Roughly 10% of people worldwide suffer from osteoarthritis (OA), an irreversible degenerative joint disease that causes pain and impairment. Aim of the study: To assess of knowledge and physical health status for women about knee osteoarthritis Research design: This study used a descriptive study design. Setting: The orthopedic outpatient clinic at Assiut University Hospital served as the study's location. A sample of (160) adult women under diagnosis knee osteoarthritis 20-65years. Tools: used in study women's interview questionnaire sheet to assessment women's knowledge about knee osteoarthritis and physical health status assessment. Results: The study sample's age ranged from 50 to 65 years old, not working (61.7%), body mass index were obese (47.5%) and have a level of knowledge very little about knee osteoarthritis (50%). Conclusion: The majority of the study women were have pain while walking in flat surface, ascending or descending stair while stuffiness, stiffness in the morning and problems while raising from setting on the floor, use stair while carrying heavy things, using water closed and having heavy domestic duties and half of the study sample (50%) had knowledge very little about knee osteoarthritis. Recommendations: Provide educational program for women with knee osteoarthritis that about diet, exercises, weight reduction and medication and continuously training courses for nurses about how to deal with patients with knee osteoarthritis.