Background: Coronavirus disease 2019 (COVID-19) has been rapidly and internationally spreading, with detrimental impacts on economy and health. A vital part of medical care is nursing, and nurses' skills, attitudes, and knowledge about the prevention and control of the disease directly affects patient's outcomes during the COVID-19 epidemic. Aim: To assess nurses' knowledge, attitude, and practices toward Covid-19 in maternal and child health Centers. Methods: Descriptive research design. Settings Maternal and Child Health centers at Assiut City included 110 Nurses. Tools: Included Tools (I) part (1): Personal data, part (2): Nurses' knowledge. Tool (II): Nurses' attitude toward Covid-19. Tool (III): Observational checklist of Nurses' practices toward coronavirus disease 2019. Results: shown that 67.3% of Nurses Were had a low knowledge score, 58% had positive attitude regarding the coronavirus disease and 66% of them were had unsatisfactory practices. there was statistically significant difference between the nurse' age and years of experience with total Knowledge, there was not statistically significant difference between the nurse' age and Level of Education with total attitude and there was statistically significant between the nurse' age and Years of experience with total practices. Conclusion: The majority of the nurses who were studied had poor scores of knowledge and positive attitudes regarding coronavirus disease, the most of them engaged in unsatisfactory practices. Recommendations: In-services training programs about coronavirus disease should be focus on maternal and child health nurses