Background: Maternal prenatal anxiety plays an obvious role in adverse obstetrical problems such as preterm labor and low birth weight. Distraction technique and relaxation exercise can reduce the anxiety level and improve quality of life among threatened Preterm Labor women. Aim: this research aimed to evaluate the effect of distraction technique and relaxation exercise on anxiety level and quality of life among threatened Preterm labor women. Design: the study used a quasi-experimental design. Methods: the study included 200 pregnant women who diagnosed with threatened preterm labor in which they divided into intervention and control group (100 women for each group). Setting: Obstetrical and gynecological inpatient department at Suez Canal university hospitals, Ismailia Governorate, Egypt between the periods of May 2023 to April 2024. Tools: In the present research, three tools were used. Tool (I): Pregnant women identification form. Tool (II): Beck Anxiety Inventory and Tool (III): The Quality of Life Enjoyment and Satisfaction Questionnaire–Short Form. Results: The mean quality of life score was improved, rising from 25.8±2.7 before the intervention to 60±7.4 after it. The average anxiety score dropped from 52.4±4.6 prior to the intervention to 22±5.5 after it. These improvements were statistically significant (p < 0.00001). Conclusion: Distraction technique and relaxation exercise are effective in reducing anxiety level and improving quality of life among women with preterm labor. Recommendations: Nurses and midwives should consider incorporating medical therapy with relaxation exercise and distraction techniques in women diagnosed with preterm labor.