Background: Perimenopause starts many years before menopause and is the starting point for women's reproductive aging. It is characterized by wide range of menopausal symptoms. Lifestyle modification is suggested as the first line of treatment for women with perimenopausal symptoms. Aim of the study: The study aims to evaluate the effect of life style modifications on improving the perimenopausal symptoms among women. Subjects and methods: Quasiexperimental study with a pre-post-test design of 120 perimenopausal women collected by using a purposive sample, conducted at gynecology clinic and general medicine clinic at Assuit university hospitals within 7 months from January to July 2023. Four tools were used for this study, structured interviewing questionnaire, menopausal rating scale, health promotion lifestyle profile and follow up sheet. Results: This study reveals that There was a highly statistically significant difference regarding the mean of total score of all subscales of MRS including (somatic, psychological and urogenital) of perimenopausal women before and after healthy life style modifications (P=0.001). There was a highly statistically significant difference (P=0.001) regarding total Health-Promoting Lifestyle Profile (HPLP) levels before and after health education. Conclusion: the healthy lifestyle modifications were very effective in improving the women's perimenopausal symptoms. Health education plays an important role in improving the women's unhealthy lifestyle behaviors. Recommendations: Conduct further research with longer observation period and bigger sample size to determine the impact of life style modifications on reducing women's perimenopausal symptoms.