Background: Occupational health for employees in any organization is crucial as it is a branch of public healthcare concerned with all aspects of safety and health in the workplace, with a strong focus on the prevention of risks. Aim: Evaluate the occupational health hazards and safety measures among workers at Kima Factory at Aswan City. Design: A descriptive research design was employedin this study. Setting: The study was performed at Kima Fertilizers and Chemicals Factory in Aswan City. Sample: A systematic random sample of 332 workers was employed. Tools: Data collection was carried out using two tools. Tool (I): An interviewing questionnaire sheet comprised three parts: Part one: Socio-demographic characteristics and work data of participants. Part two: History of occupational injury or problem. Part three: Worker's knowledge about occupational health hazards. Tool II: Observational checklist to evaluate worker's practice. Results: The study revealed that 46.1% of the workers possess (an adequate level of) not poor knowledge about occupational hazards at Kima Fertilizers and Chemicals Factory in Aswan City. Additionally, 76.2% of the workers demonstrated a satisfactory level of practice concerning the use of personal protective equipment. Conclusion: There was a statistically significant correlation (P = 0.043) among the overall level of knowledge and the overall level of practice within the studied workers. Recommendations: Implement and advance training programs for workers to enhance their practices and knowledge related to occupational health risks.