Background: Sexuality is a basic human need. It is among the extremely important & complex facets of a woman's existence. Relationship between infertility and sexual dysfunctions can be mutual as sexual dysfunctions can be a cause of infertility or can be triggered by infertility. Aim: of the study to evaluate effect of life style modification on sexual dysfunction among infertile women. Methods: Sample: purposive sample of 60 infertile women, Research Design: quasi-experimental with a pre-post-test design was adopted. Study setting: This study was conducted at the assisted reproductive technology unit (ART unit) & outpatient gynecological clinic at Women's Health Hospital, Assiut University. Study tools: including structured interviewing questionnaire, Arabic version of female sexual dysfunction index & follow up sheet. Results: the investigation outcomes revealed that before intervention (90%) of the studied women suffer from sexual dysfunction while after intervention, female sexual dysfunction was significantly improved (P < 0.01), as its percentage decreased to (3.3%). A strong statistically significant association was found between sexual dysfunction and both educational attainment (p=0.009),and profession (p=0.004). Conclusion: life style modification was effective in improving sexual dysfunction among infertile women as before intervention majority of the studied women were experience sexual dysfunction while after intervention female sexual dysfunction was significantly improved. Recommendations: Adopting healthy lifestyle patterns should be taken into account for all women who experience sexual dysfunction to help them have positive & satisfying sexual relationship.