Background: Chronic obstructive pulmonary disease is a serious health issue which classified as the third most common cause of death globally. It causes dynamic hyperinflation as the illness deteriorates over time, causing dyspnoea and changes in the heart's functioning in individuals. Patients with pulmonary disease frequently employ pursed lip and/or pranayama breathing exercise to alleviate dyspnoea, improve gas exchange, and increase ventilation efficiency. Aim: To investigate the effect of pursed-lip versus pranayama breathing exercises on selected vital parameters among patients with chronic obstructive pulmonary disease. Design: Quasi-experimental design (non-equivalent, pre-post-test control group) was utilized. Setting: This study was conducted at one of the teaching hospital of Cairo University, Egypt. Sample: A purposive sample of 90 adult male & female patients. Tools: three tools were used (1) Demographic and Medical History Data Sheet, (2) Observational sheet, & (3) Dyspnoea Index questionnaire. Results: Statistical significant difference was observed at 4 weeks following interventions between the three groups regarding dyspnoea score (F = 197.463, P value: 0.000), respiratory rate (F = 213.112, P value: 0.000) and oxygen saturation (F = 25.779, P value: 0.040). Conclusion: With an exception of heart rate, high statistical significant difference was observed in the control group and the two intervention groups regarding the rest of selected vital parameters and dyspnoea score. Significant improvement was observed among the pursed lip intervention group. Recommendations: Pulmonary rehabilitation program should be offered to those patients including pursed lip and pranayama breathing exercises.