Background: The inverted nipple is the most encountered problem that leads to difficulties with breastfeeding; it is an indicator of serious breast issue. Many strategies have been proposed to manage the inverted nipple. The aim of this study: was to assess the effect of nursing interventions strategies for inverted nipple on efficiency of early breastfeeding among primiparous mothers. Subjects and Method: Quasi experimental research design was used to conduct this study at postnatal ward of Tanta University and El-Menshawy Hospitals. The study sample consisted of 100 primiparous mothers with inverted nipple, Group (1): 50 primiparous mothers used syringe technique. Group (2): 50 primiparous mothers used Hoffman's exercise. Data collection was conducted using three tools, Tool I: Mothers′ knowledge regarding inverted nipple structured questionnaire, Tool II: LATCH assessment scale and Tool III: Infant breastfeeding assessment tool (IBFAT). Results: There was a significant statistical improvement in the overall knowledge, LATCH, and IBFAT in Hoffman and syringe groups after implementation of nursing intervention strategies. Additionally, there were positive correlation between the studied primiparous mothers′ total score level of knowledge, total LATCH and their total infant breastfeeding in Hoffman and syringe groups' pre –intervention, the end of 1st week after delivery and the end of the postpartum period. Conclusion: The findings of the present study revealed significant improvement in the mothers′ knowledge, LATCH, and level of IBFAT in Hoffman and syringe groups after implementation of nursing intervention strategies. Recommendation: It is recommended to develop training programs for mothers in order to improve their knowledge and practices regarding inverted nipple