Patients with intensive care unit require mechanical ventilation for a number of reasons. Although it has advantages, there could be a higher chance of serious consequences. Therefore, an evidence-based series of procedures referred to as the liberation bundle when taken together, will improve the prognosis for patients on mechanical ventilation. Aim of study: This study aimed to investigate effect of implementation ICU liberation bundle on critically Ill patients outcomes. Design: Quasi experimental research design was used to conduct this research. Setting: This study was carried out at intensive care unit at Asyut University Hospitals. Sample: 60 patients, divided equally into study and control groups30 patients for each. Tools included four tools Tool 1: Patient assessment sheet Tool 2: Assessing muscle strength sheet Tool 3: Family Engagement Assessment Sheet Tool 4: Patients outcomes assessment Sheet. Results: - Findings of the present study revealed that study group had lowered the mean pain score was 1.17±1.63compared to 5.40±1.43 for the control group. Also study group had a significantly shorter time of mechanical ventilation connection 1.63±0.96 days for study group and 8.58±3.82 for control group that resulting in shorter length of hospital stays for the study group 7.83±1.29 compared to control 17.10±4.46. Conclusion: Implementing liberation bundle is an effective approach in critically ill patients and it has lower intensive care stay duration, lower mortality rate and period on ventilator. Recommendation: Encouraging early mobilization, family involvement, and the implementation the liberation bundle for patients in intensive care units to enhance patient outcomes.