Background: Pregnant women are more vulnerable to heat stress than non-pregnant women, and greater attention should be prioritized to climate change, which has a negative impact on maternal and fetal health during pregnancy. This study aimed to investigate the effect of motivational interviewing on pregnant women's health awareness and risk perception regarding climate change. Study Design: A quasi-experimental one-group pre-post-test design was utilized. Study Setting: The Antenatal Outpatient Clinic of Obstetrics and Gynecological Specialty Center of Mansoura University Hospital, Dakahlia Governorate, Egypt. Study Subjects: A convenient sample of 69 pregnant women were recruited. Study Tools: Three tools were used for data collection, structured interview questionnaire, pregnant women's risk perception scale, and structured daily life practices interview questionnaire. Results: Postintervention, 86.1% of the pregnant women exhibited good knowledge regarding climate change as compared to 95.7% exhibited poor knowledge pre-intervention. Concerning the risk perception score, it was significantly improved post-intervention as compared to pre-intervention (94.2% vs. 42%, respectively). Moreover, a significant positive shift in the total practices score of pregnant women related to climate change post-intervention as compared to pre-intervention (85.7% vs. 68.1%, respectively). Conclusion: The majority of pregnant women had significantly improved their knowledge, risk perception, and practices about climate change after applying the motivational interviewing sessions. Recommendation: Apply antenatal motivational interviewing sessions to enlighten pregnant women on how to mitigate the harmful effects of climate change.