Abstract Background: Emergency nurses play a critical role in providing proper nursing care services for dog bites, Rabies affects all mammals (bats, monkeys, wolves, jackals, cats, and foxes) Aim of the study: To assess knowledge and performance of emergency nurses about dog bites care at emergency unit. Research design: A descriptive exploratory research design was used in the conduction for this study. Setting: This study conducted in emergency departments at General Assuit Hospital (Shamla Hospital- Assuit) Sample: A convenient sample who were 60 nurses at emergency departments at Assuit General Hospital. Tools: This study included two tools: Tool (I): Nurses Knowledge assessment tool. Tool (II): Dog bites checklist emergency nurse's performance tool. Results: study results revealed that the most of total score knowledge about of dog bite have good level total knowledge score (45.0%) and unsatisfactory level practice about dog bite tool (60.0%), P. Value reflects that there is no correlation between the socio-demographic data and the level of knowledge, P. Value reflects that there is correlation between the socio-demographic data and nurse's performance and relationship between emergency nurse's knowledge of dog bite and dog bites checklist emergency nurse's performance that negative correlation. Conclusion: knowledge about dog bites care have good level total knowledge and unsatisfactory level total practice about dog bites care. Recommendation: Regarding nursing knowledge continuing educational programs about dog bites care and should be regularly done and updated in view of changing knowledge.