Abstract Background: There are numerous detrimental impacts of climate change on health, including heart health. The elderly, those with pre-existing medical illnesses including acute heartdisease, and those who have physically demanding jobs are especially at risk. Aim: The aim of this study was to assess effect of climate changes on acute heart diseases at Assiut University Heart Hospital. Research design: The study design used was descriptive and correlational. Setting: The study was carried out in the emergency heart unit and the coronary care unit, At Assiut University Heart Hospital. Patients: This study included 130 adult patients, both male and female, with acute cardiac diseases. Tools: Three instruments were employed: the patient outcomes tool, the assessment sheet for climatic changes, and the assessment sheet for acute cardiac diseases. Results: It was noted that three fifths of the studied patients (60.8%) were admitted to the coronary care unit during the summer. Additionally, research showed that temperature and partial thromboplastin time had a positive link (p=0.007). Conclusion: The study's conclusion was that a majority of the patients diagnosed with ST-Elevation myocardial infarction and who were hospitalized to the coronary care unit during the summer were from rural areas. Furthermore, there was a positive correlation between temperature and partial thromboplastin time. The length of stay in the cardiac intensive care unit was positively impacted by the rain and temperature. Recommendation: According to the current study, additional research is required to assess the consequences of climate change on individuals with acute heart diseases.