Abstract Total knee arthroplasty (TKA) is a successful therapeutic option that can improve function, reduce discomfort, and enhance quality of life for those with symptomatic osteoarthritis. Effective Preoperative patient education combined with Kinesio taping is crucial to speed up recuperation following TKA. The study aimed to evaluate the efficacy of preoperative nursing education with Kinesio taping application on functional outcomes of patients undergoing TKA. Quasi-experimental research design: was used. The orthopedic departments at Mansoura University Hospital and New General Mansoura Hospital, Egypt served as the study setting. Sample: 80 patients were enrolled to conduct the study. Tools: Demographic characteristics, clinical data, and the knowledge assessment questionnaire (Tool I), Patient's practices following TKA surgery checklist (Tool II), and the Knee Outcome Survey Activities of Daily Living Scale (Tool III). Results: Showed a statistically significant improvement in the intervention group's total mean knowledge scores compared to the control group both immediately after the educational intervention (51.35±12.49, 30.88±11.17) and two months later (49.15±12.76, 30.30±10.19). In addition, the intervention group's overall mean practice scores following TKA and after the application of educational intervention and Kinesio tape (8.63±3.04) were considerably better than those of the control group (5.25±2.23). Furthermore, after applying educational intervention and Kinesio tape, the intervention group's overall mean scores of the KOS-ADLS improved statistically significantly (to 51.28±8.89) compared to preoperatively (44.53±8.38). Conclusion: The application of preoperative nursing education with Kinesio taping significantly improved the functional outcomes of patients undergoing TKA. Recommendations: Application of TKA preoperative nursing education and Kinesio taping by staff nurses working in orthopedic departments.