Background: Acceptance of artificial intelligence technologies in ICU facilitate practice nurses and make it possible for them to give their patients the best possible care. Aim: to assess perception and attitude of critical care nurses regarding artificial intelligence at intensive care unit. Study design: A descriptive research design was used to collect data of the present study. Setting: The present study was carried out in ICU of Assiut university Hospital and at Assiut General Hospital. Sample: All available nurses in ICU at Assiut university Hospital and at Assiut General Hospital. Tools: tool one: critical care nurse's perception of AI scale tool two: nursesꞌ attitudes towards artificial intelligence scale. Results: The results showed that 83.3% of critical care nurses had moderate perception toward usage of AI in ICU and 86.7% of nurses had positive attitude toward usage of AI in ICU. A greatly significant positive connection between of critical care nurses' perception and attitude toward usage of AI in ICU was found. Conclusions: The majority of nurses of critical care had moderate perception and positive attitude toward usage of artificial intelligence in ICU. Recommendations: Performing a scientific researches concentrated on artificially intelligent in ICU at Egypt and to give different findings. preparing training programs for ICU nurses to Inform them of the possible uses of AI.