Background: Several invasive devices are connected daily in intensive care patients. It is evident that complications associated with these invasive devices and are potentially life threatening. Aim of the study: Explore the effect of invasive devices on occurrence of complications and mortality rate among intensive care patients. Research design: Prospective correlational research design. Setting: Intensive Care Units as Coronary ICU, Cardio-Thoracic SICU, Trauma ICU, Medical ICU, General ICU, Critical ICU, Neuro-stroke ICU, Neuro SICU and Gastrointestinal ICU, all at Assiut University Hospitals. Patients: Intensive care patients (160), were assigned into two groups (68 patients had one or two invasive devices and 92 patients had three or more invasive devices). Tools: Adult critically ill patient assessment tool and patient outcome assessment tool. Results: Critically ill patients who had many invasive devices were exposed to higher complications and mortality rate (89.1% & 55.4% versus 14.7% & 2.9%) in those who have few invasive devices, respectively. Conclusions: Increased number of invasive devices was linked to a greater mortality rate and a higher incidence of complications. Recommendations: Continuously reducing number and also following care bundles for insertion, maintaining and removal of all invasive devices connected with intensive care patients.