Background: Mind mapping is a smart and attractive method that used for learning advancement and makes recalling information more clear and easy. Aim: Identify the effect of mind mapping with artificial intelligence for high alert medications on novice nurses performance at intensive care unit of neonate. Design: The study design used was quasi-experimental. Setting: This study was conducted at neonates' intensive care units at Tanta University Main Hospital and International Teaching Hospitals. Sample: A purposive sample of all novice nurses (30) who were working in the previously declared places. Tools: Two tools were involved .Tool (I): High alert medications knowledge questionnaire. Tool (II): High alert medications observational checklist. Results: All nurses (100%) showed high level of knowledge immediately after implementing mind mapping contrary to one month of implementing it as this percentage declined to 86.7%. In addition, all studied nurses (100%) demonstrated unsatisfactory level of practices before implementation of mind mapping while majority of them (96.7%) demonstrated satisfactory level of practices immediately following using mind mapping then this percentage reached to76.7% after one month. Conclusion: Mind mapping with artificial intelligence had a positive effect on neonatal intensive care unit novice nurses' performance regarding high alert medications. Recommendation: Conduct periodic in-service educational training utilizing innovative teaching techniques such as mind mapping and artificial intelligence to improve novice nurses' performance about high alert drugs.