Abstract Background: After giving birth, women go through a time known as the postpartum phase during which they adjust both physically and mentally. This study aimed to assess of knowledge and Identify practices for women who delivered cesarean section during postpartum period. Subjects and Methods: A Descriptive research design was conducted. Setting: This study was carried out in postpartum department at Al-Eman General Hospital in Assiut city. Sample: A Convenient sample (120) of all available studied women. Data collection tools: Data were collected by three tools: Tool (1): Structured interviewing questionnaire, Tool(2) knowledge Assessment Tool, Tool(3) Observational checked list regarding self –care practices level of the pregnant women regarding postpartum and new born care. Results: The current study findings showed that only 29.2% of them had good while 70.8% had poor knowledge regarding postpartum and new-born care and 73.3% of the studied postpartum women had satisfactory and 26.7% had unsatisfactory level of practices about post-partum self-care. There were a high significant relation between total score of women's knowledge and total score of women's practices about post partum self-care Conclusion: About more than two thirds of the postpartum women had poor knowledge regarding postpartum car and new-born care and less than three quarters and more than one quarter of the studied women had satisfactory and unsatisfactory level of practices about post-partum self-care. Recommendation: Give health education supported by drawing pamphlets about postpartum self and neonatal care on discharge for postpartum the women.