Background: After an appendectomy, post-operative nausea and vomiting still cause problems. It is still the most typical anesthesia related post-operative complications. Aim of the preset study was to determine the efficacy of acupressure versus deep breathing exercise on post-operative nausea and vomiting in children. Subjects and method: This study was conducted at Assiut University Children Hospital's pediatric surgery unit; a quasi-experimental research design was used. This trial involved ninety children, who were split randomly into three groups: the acupressure group, the deep breathing exercise group and the control group. Four tools were used to get the data of this study. Tool (I): Biosocial demographic questionnaire form. Tool (II): Nausea assessment form. Tool (III): Vomiting assessment form. Tool (IV): Rhodes index of nausea and vomiting. The results of this study showed that a statistically significant difference (p-value of 0.001) was seen between the intervention groups and the control group, indicating that acupressure and deep breathing exercise were beneficial in reducing post-operative nausea and vomiting. The researchers concluded that acupressure was marginally more beneficial than deep breathing exercise, but there were no statistically significant differences between the two intervention groups. Researchers recommended that one of the post-operative modalities for managing nausea and vomiting should be the regular use of acupressure and deep breathing exercise.