Background: Inter-professional collaboration is important not only for better health outcomes, but also can help to improve the quality of care provided and enhance the professional competency of knowledge management and career success among nurses. Aim: The study aimed to explore inter-professional collaboration and knowledge management as an indicator of career success among nurses. Research Design: The study used a descriptive correlational design. Setting: The study was carried out in critical care units (13unit) at Benha University Hospital. Sample: All available of nurses 418 out of 421. Tools of data collection: Three main tools namely; I): Interprofessional collaboration questionnaire II): Knowledge management scale and III): Subjective Career Success Scale (SCSS) Results: Showed that more than three fifth (64.6%) of studied nurses had high level of perception toward inter-professional collaboration and more than half (52.9%) of them reported moderate level of knowledge management. While, more than three fifth (63.9%) of nurses reported moderate level of career success. Conclusion: There was a highly positive statistically significant correlation among total inter-professional collaboration, total knowledge management and total career success among nurses. Recommendations: Providing training programs and workshops for nurses about inter-professional collaboration to improve quality of patient care. Hospital administration should support knowledge management practices through investment in its infrastructure and technologies.