Abstract Background: Because self-management is linked to better clinical outcomes, it is becoming more and more crucial for patients with chronic obstructive pulmonary disease (COPD). The aim of the study: To evaluate the effect of self-management teaching strategies on chronic obstructive pulmonary disease patients with dyspnea. Research design: Quasi-experimental (pre-post) research design was utilized. Subjects and methods: A purposive sample of 40 adult patients diagnosed with COPD. A study was conducted in the chest department and outpatient clinic at Assiut University Hospital. Tools: Three tools were utilized; a Patient assessment sheet, a Modified Medical Research Council Dyspnea Scale (mMRC), and a Dyspnea Management Questionnaire (DMQ). Results: The mean age of the studied patients was 58.87±6.38 years, 67.5% of patients were males, and more than half of patients were current cigarette smokers 52.5%. After three months of applying the strategies a significant decrease in Modified Medical Research Council Dyspnea Scale (mMRC) was found post-intervention compared with that pre-intervention (P = ≤ 0.001). There was a statistically significant difference between pre\post strategies application reflected a positive influence on patients' levels of dyspnea which in turn improved their quality of life in all dimensions of the dyspnea management scale (dyspnea intensity, dyspnea anxiety, activity avoidance, self-efficacy, and strategies satisfaction) (P = ≤ 0.001). Conclusion: This study showed that self-management strategies could reduce dyspnea of patients with COPD and improve the health status. Recommendation: Provide booklet with sufficient relevant written and visual information to each COPD patient for controlling episodic dyspnea.