Background: The nursing profession is crucial to providing patients with high-standard medical care. Achieving the best possible patient outcomes depends heavily on nursing practitioners who possess the necessary competences and the roles. Aim: Determine the effect of technology on quality of work life for nursing staff and patient satisfaction. Methods: Descriptive research design was used in this study. Setting: It was conducted in the El-Rajhy Hospital at Assiut University. Subjects: A total number of 173 nurses and 112 patients was involved in the study. Data collection: it includes two parts part I: include two tools were used self-administered questionnaire for nurses, personal data and quality of wok life scale. Part II: include two tools were used structured interview questionnaire for patients, socio demographic data and patient satisfaction questionnaire. Results: majority of studied nurses had good and 8.1% had poor quality of work life, 83.9% of studied patients, had satisfied. Conclusion: the majority of the studied nurses and had good quality of work life and the majority of patients were satisfied by technology. Recommendations: Carryout In-service training programs in other healthcare setting regarding using technology in other hospitals for enhancing quality of work life, and pay attention adding new features to the system to meet new needs in all future health care setting.