Background: Acute complications in arrhythmic patients undergoing cardiac electrophysiology study (EPS) can have significant clinical implications. Assessing these complications is crucial for optimizing patient care. Aim; Assessment of acute complications for arrhythmic patients undergoing cardiac electrophysiology study. Research design: Descriptive research design was utilized. Setting: The study was conducted in cardiac catheterization unit at Assuit University Heart Hospital. Sample: sixty adult patients underwent EPS. Tools, Tool (I): Patient's assessment sheet, Tool (II): Patient's complications assessment sheet. Results: Out of the studied patients (60) who underwent EPS, three patients encountered major complications, two of them (2.3%) developed atrioventricular block, while one patient experienced deep venous thrombosis. Minor complications were experienced by 25.0% of the total studied patients. Heart disease (P value, 0.022), hypertension (P-value, 0.025), and smoking (P-value, 0.040), identified as significant predictor for EPS complications. Conclusion: Cardiac electrophysiology studies demonstrated a low incidence of complications, with hypertension, heart disease, and smoking identified as potential risk factors. Overall, EPS appears to be a safe procedure for diagnosing and treating cardiac arrhythmias. Recommendation: Nursing protocol must be implemented for nurses, who are integral in patient care, regarding the acute complications associated with cardiac electrophysiology studies for early recognition and management.