Tele-nursing can provide patients with leg ulcers access to educational resources and self-management tools. Also empower patients with knowledge and skills to manage their condition. Purpose: to determine the effect of Tele nursing intervention on Knowledge and Quality of Life for Patient with Chronic Venous Leg Ulcer. Design: Quasi experimental research. Setting: The study was conducted at the surgical department and outpatient clinics at Menoufia University Hospital- Egypt. Subjects: Eighty patients with venous leg ulcers were randomly assigned into two groups; study group (receiving educational telephone follow-up interventions) and control group (Receiving hospital management instruction). Instruments: I) Structured interviewing questionnaire; it includes: Sociodemographic and Medical data. II) Knowledge assessment questionnaire. III) Short Form – 12 Health Survey quality of life questionnaires. Results: There was statistically improvement in the mean total knowledge score in study group compared to control group post conducting tele-nursing intervention (from 21.42& 19.87 to 48.22&29.52) respectively. The mean QoL scores were changing from (30.42±1.81&30.30±1.22 to 31.95±1.75 & 30.70±1.34) in study and control group pre and post tele-nursing intervention (after 12 month) respectively, with statistically significant difference. Conclusion: Tele-nursing intervention has a great effect on enhancing quality of life of patient with chronic venous leg ulcer. Recommendation: Tele nursing approach should be utilized to facilitate nursing tasks and safely and effectively improve patients' quality of life is a part of systematic nursing practice.