Diabetes is a worldwide chronic disease with high prevalence especially in developing countries. In addition to its physical complications, diabetic patients are at high risk of suffering a wide spectrum of psychological disorders as negative emotions. Aim: To evaluate and compare the effectiveness of Reiki and Qi-gong therapy techniques in improving diabetic patients' negative emotional states. This quas-experimental research design was carried out at the National Institute of Diabetes and Endocrinology's Hospital in Cairo, Egypt. It included 200 Type 2 diabetes patients randomized into two equal groups, one for Qigong and one for Reiki techniques. A self-administered questionnaire with a standardized tool (Depression Anxiety Stress Scales [DASS[) was used in data collection. The intervention programs were administered in the form of instructional guidelines through eight sessions for each group. The results showed that the two study groups had similar socio-demographic characteristics. After implementation of the intervention, most patients in the two groups were having no anxiety, no depression, and no stress. Statistically significant improvements in all three parameters in both groups (p < 0.001). The multivariate analysis identified the study intervention as the main statistically significant independent negative predictor of the patients' scores of anxiety, depression, and stress. Reiki technique was also a statistically significant independent negative predictor of these scores. Both Reiki and Qi-gong therapy techniques were effective in improving diabetic patients' negative emotional states of anxiety, depression, and stress, with slight superiority of the Reiki technique. The inclusion of these techniques in the management plans of Type-2 diabetic patients is recommended.