Background: Interns face many stressors that can affect their work and overall well-being. Emotionally intelligent nurses think positively and live fulfilling lives, which reduces their perceived stress. Aim: of this study was to examine the mediating role of emotional intelligence in the relationship between perceived stress and life satisfaction among nursing intern students. Design: A descriptive correlational research design was utilized. Sample: Convenient sample of 200 of 375 internship-year students. Setting: Data was gathered from several clinical settings where nursing intern students were trained at Kasr El-Aini hospital. Tools: Four tools were used, Personal characteristics data sheet, Emotional Intelligence questionnaire, Perceived stress questionnaire, and Life satisfaction scale. Results: This study found that 61.0% of participants were females. Most (83%) were single. (68.5%) nursing intern students exhibited high emotional intelligence, (62%), moderate stress, and (88.5%) moderate life satisfaction. Nursing intern students' perceived stress levels were negatively correlated with their life satisfaction but not with their emotional intelligence. Conclusion: Emotional intelligence did not mediate the connection between stress and life satisfaction. Also it was found that there was a direct negative relationship between perceived stress levels and Life satisfaction levels. Recommendation: Further research with larger sample sizes is recommended to generalize and enhance the understanding of the connection between emotional intelligence, perceived stress, and life satisfaction among this specific group of students.