Background: Anemia is global health problem among population resulting in an impaired oxygen-carrying capacity to meet the tissues' physiological demands. Thus, Alternate Nostrils Breathing is one of the most beneficial, exercise that could improve health status. Aim: Was to evaluate the effect of Alternate Nostrils Breathing Exercise on selected outcomes among patients with anemia. Design: Quasi Experimental (Pre-Post) test, Non-equivalent control group design. Sample: Purposive sample of 60 patients their age was from 18 years old and had mild or moderate anemia. Setting: It was conducted at the Medical and Surgical Departments at one of an Educational Hospital (Kasr AL Ainy Hospital); Egypt Tools: Tool (1) Demographic Medical Data Form (DMDF). Tool (2) Research and Development (RAND) 36-Short Form Ver. 1.0. Results: Regarding demographic and medical parameters were homogenous. There was a statistically significant difference between the study and the control groups at post measurements with highly significant difference at the second post measurement regarding respiratory rate and oxygen saturation as (t-test=12.03 and 5.29 respectively; both was at p value=0.000). Moreover, health status total average mean scores of both study and control groups pre-test were homogenous as (t-test= 1.29 at p value=0.20). While there was a statistically significant mean of difference at post measurements with highest significant result at the second post measurement as (t-test= 13.33 at p value=0.000). Conclusion: Respiratory rate, oxygen saturation and health status parameters were improved for study group after implementation of Alternate Nostrils Breathing exercise. Recommendations: Practicing of Alternate Nostrils Breathing Exercise should take a place for patients with different types of anemia