Background: With developing substance use patterns, in Egypt substance abuse rabidly increased and new substances were added every day. According to the latest data, 5.5% of individuals worldwide, aged 15 to 64, reported using drugs or alcohol at least once in the preceding year. The widespread issue of addiction to substances can devastate the individual's relationships, income, and economy. This study aimed to: Identify the patterns of substance addiction among male individuals with substance addiction admitted at Assiut university hospital.Subjects and methods: A descriptive research design was used. The study subjects included 62 male individuals with substance addiction. Setting: At the inpatient sector of addiction management unit at the Psychiatry, Neurology and Neurosurgery Hospitalat Assiut University.Purposive sample was utilized. Tools: A Self-administered questionnaire about socio-demographic and clinical characteristics, scale for measuring family socioeconomic status and the addiction severity index (ASI). Results: More than half of individuals with addiction use single substance, the most prevalent substance used the opioid (62.9%), followed by tramadol (32.3%), amphetamines (25.8%), cannabinoids (19.0%) and benzodiazepine (4.8%).And more than two thirds of individuals with substance addiction initiating substance due to their peer negative effect. Conclusions: The most prevalent substance used opioid and most individuals with substance addiction initiating substance due to their peer negative effect. Recommendations: Continuously identifying the new patterns of substance addiction, ways of prevention to substance addiction and appropriate interventions for its treatment.