Background: Staff nurses' strain are reported among oncology nurses to affect coping strategies and dramatically and rapidly causing fundamental transformations that have an impact on staff nurses performance.Aims: To explore effects of job strain coping strategies on nurses performance. Research design: Descriptive correlation design was used. Setting: South Egypt Cancer Institute, Assiut University. Subject: Consisted of 320 nursing staff. Tools: Three tools were used; Personal characteristics data sheet, Job Content Questionnaire, Revised Ways of Coping Questionnaire and Observational Performance Checklist. Results: The highest percent of nursing staff apply coping strategies. There is a high statistical significant correlation between problem focused coping strategies , gender, marital status, level of education, occupation, and attending training courses of the studied nursing staff .(0.027*,0.037* ,0.001* ,0.006* ,0.000*). There is a high statistical significant correlation between emotion focused coping strategies, level of education, occupation, and attending training courses of the studied nursing staff. (0.001*, 0.003*, 0.000*) Conclusion: There is a negative statistical correlation between job strain, coping strategies and nurses performance (-0.004* and 0.000* respectively). Recommendation: Providing workshops and training programs for nurses about the role of coping strategies in reducing job strain and improving work performance.