Background: Changes of voice and neck discomfort are two undesirable outcomes after thyroidectomy operations that are related to local wound adhesion. Aim: To evaluate whether teaching protocol of neck exercises and wound massage can reduce wound adhesion and voice changes among post-thyroidectomy patients. Research design: A quasi-experimental research design (study/ control) was utilized to conduct this study. Sample: A purposeful sample of 60 adult patients. Patients were divided into two groups as study (n = 30) and control (n = 30). Setting: The study was conducted in the General Surgical Departments (A, B, and C) and General Surgical Outpatient Clinic at Main Assiut University Hospital. Tools: Four tools were utilized; Tool (I): A structured interview questionnaire, Tool (II): The patient and observer scar assessment scale (POSAS), Tool (III): Voice Handicap Index (VHI-10) questionnaire & Tool (IV): Compliance assessment sheet. Results: There were highly statistically significant differences between study and control groups regarding wound adhesion and voice changes after applying the teaching protocol of neck exercises and wound massage (2 and 4weeks postoperatively) (P-value<0.001**). Conclusion: Applying a teaching protocol of neck exercises and wound massage post- thyroidectomy significantly reduced wound adhesion and improved voice changes in the study group compared to the control group. Recommendations: Neck exercises and wound massage are recommended to be an integral part of the pre-operative nursing teaching for patients undergoing thyroidectomy and a booklet should be available at the surgical wards as a reference.