Background and aim: Teach-back is a method of confirming what the patients know by using their own language. It is a communication approach as well as healthcare before providing any additional details, the professional provides the details and then encourages the individual in question to respond and confirm their understanding. Aim: It was to assess the impact of teach back based self-care program on postpartum health-related quality of life (QoL) among primiparous women. Methods: The current study was conducted using a quasi-experimental research methodology (Pre-Posttest). Setting: This research was applied at the post-natal follow-up clinics and the well-baby clinics of Maternal and Child Health Center in Shebin Elkoom, Menofyia Governorate Sample: Based on the sample calculation, a purposive sample of 60 women was selected. Instruments: For data collection, two instruments were used: (1) a structured interviewing questionnaire and (2) a health-related QoL questionnaire (WHOQOL-BREF). Results: There was a significant difference between pre and post intervention stages as regard to physical, psychological, personal and environment domains of studied women. Higher health-related QoL scores revealed significant changes between pre- and post-implementation of a teach back-based self-care program. Conclusion: The current study found a significant increase in postpartum health-related QoL after the application of teach-back based self-care program. The current findings allow the first study hypothesis to be accepted. Recommendations: Reinforce using teach-back based self-care program as a portion of routine postpartum care. Replication of the study with larger sample from different settings to advance testing different determinants of health related QoL.