Trauma patients require mechanical ventilation for variety of reasons. Despite its benefits, it may increase the risk of deadly consequences. This can be minimized or prevented. Therefore, a series of evidence-based interventions called ventilator care bundle VCB  when applied with each other will achieve positive outcomes of patients  on mechanical ventilation. Aim of study: this study aimed to investigate the effect of implementing ventilator care bundle on mechanically ventilated patient outcomes. Design: Quasi experimental research design was used to conduct this research. Setting: This study was carried out at trauma ICU at Assiut University Hospitals.  Sample consisted of 60 patients, divided into study and control groups equally. Tools included three tools. Tool I: - Ventilator Care Bundle audit form, Tool II: - Weaning Trial and Extubation Assessment,Tool III: - Mechanically ventilated patient Outcomes Indicators. Results: - Findings of the present study revealed that  study group had lower incidence of  ventilator-associated pneumonia VAP 30% compared to 73.3% for control group. As regard to oral cavity assessment  the majority of study patients 80 % had no oral dysfunction compared with 0% for control group.  Also study group had a significantly shorter time of mechanical ventilation connection 6.97 ± 3.00 days for study group and 13.63 ± 6.26 for control group that resulting in shorter ICU stay for study group 11.37 ± 3.48 days compared to control group17.50 ± 6.03 days. Conclusion: Implementing ventilator care bundle is an effective approach to reduce the incidence of VAP and oral cavity dysfunction  in mechanically ventilated patients and it has lower ICU stay period, lower mortality rate and duration on ventilator. Recommendation: Further study focuses on intervention to improve care of patient- centered outcome. Replication of population from different geographical locations in Egypt for generalization.