Head nurses are challenged to make decisions effectively in addition to lead in this dynamic and uncertain nature of health care condition. Entrepreneurship is an active method of vision, alteration, as well as production that affecting head nurses decisions making and sharing their knowledge. Aim: investigate entrepreneurial leadership and its relation to decision making effectiveness and knowledge sharing behavior among head nurses at Specialized Medical Hospital. Design: Descriptive correlational design was utilized and the study was carried out on 90 head nurses working at all inpatients units at Specialized Medical Hospital. Tools: Three tools were utilized to collect data; Entrepreneurial leadership questionnaire, decision making effectiveness scale and knowledge sharing behavior scale. Results: The highest percent of head nurses showed high level of entrepreneurial leadership, decision-making effectiveness, and knowledge sharing behavior (71.1, 63.3 and 71.1) respectively. There was highly statistically significant positive correlation between entrepreneurial leadership with both head nurses' decision-making effectiveness and knowledge sharing behavior. Conclusion: Based on the findings of the present study, there was highly statistically significant positive correlation between entrepreneurial leadership with both decision-making effectiveness, and knowledge sharing behavior. Recommendations: Providing head nurses with environment that enhances their creative abilities to make effective decision and sharing their knowledge. Developing training programs that help head nurses' to recognize existing market opportunities and learn accurate strategies for effective decision-making.