Background: Menstruation is a natural phenomenon. The vast majority of women suffer from discomfort and some level of pain through their menstrual cycle, which can significantly affect their daily activities. This study aimed to assess the effect of menstrual symptoms on a daily activities among Assuit nursing secondary school students. Subjects and Methods: A Descriptive research design was conducted. Setting: This research was carried out in Assuit nursing secondary school female students at Al-Eman General Hospital in Assuit City. Sample: A convenient sample of All available nursing secondary school students (190-all levels) were including in this study Data collection tools: Data were collected by an interview questionnaire comprised of four parts: Part (1): Personal data Part(2): 7 questions regarding Menstrual data Part (3): 5 questions regarding Daily activities Part (4): 5 questions regarding Managements of menstrual symptoms Results: The results of the current study illustrated that 96.3% of the students have menstrual symptoms; the most frequent symptom (80.4%) was dysmenorrhea. While 53.2% have changed on their daily activities in a form of withdraw from social activities (58.4%). The students management of their symptoms by using hot bathes (84.7%) and (77.9%) using hot herbal drinks. Conclusion: The vast majority of the students have menstrual symptoms, more than half of them have changed on daily activities. Recommendation: Empower female adolescents with adequate knowledge about menstruation, its symptoms and management, daily activities.