Background: Urinary Incontinence is the complaint of any unintentional passing of urine which had a significant physical, psychological, sexual and social problem that affects more than half of women after menopause and this can have a profound impact on their quality of life. Consequently women tend to adopt negative or positive coping strategies to improve their quality of life. Aim of the study: Investigate the quality of life and sexual function among postmenopausal women with urinary incontinence and adopting coping strategies. Design: A descriptive design was used. Setting: The study was conducted at obstetric & gynecological outpatient clinic and the dynamic unit at urology department at outpatient clinics in Zagazig University Hospitals. Sample: A purposive sample consisted of 200 post-menopausal women. Tools of data collections: Five tools were used; Tool I: A structure interview questionnaire, Tool II: Characteristics' of urinary incontinence among post- menopausal women: Tool III: Urinary incontinence quality of life, Tool IV: Female sexual function index and Tool V: Coping strategies adopted by postmenopausal women. Results: It was found that 67% of postmenopausal women had low quality of life and all of them had a variety of sexual problem. Furthermore, 63.5% of continence postmenopausal women were used a coping strategy. Conclusion: Urinary incontinence remarkably affects quality of life and sexual function of postmenopausal women and more than three fifth of them were used coping strategies. Recommendation: Health education and training programs for post-menopausal women about urinary incontinence and appropriate coping strategies should be provided. In additions, a continuous assessment of all post-menopausal women quality of life domains for early intervention and better outcomes.