Background: Visually impaired female students have the vast efforts to maintain proper menstrual hygiene. Aim: The study aimed to assess knowledge and reported practice of visually impaired El-Nour school female students about menstrual hygiene at Sohag Governorate. Study design: A descriptive cross sectional research design was utilized in the study. Setting: The study was carried out in El-Nour school in Sohag Governorate. Sample: A cluster random sample of fifty-five (55) visually impaired female students. Tools: Tool one included two parts; part one included personal characteristics and part two included visually impaired female students' knowledge about menstrual hygiene. Tool two included the genital hygiene behaviors scale. Tool three included reported practice about perineal care. Results: 58.2% of visually impaired female students had unsatisfactory knowledge about menstrual hygiene, 63.6% of them had negative genital hygiene behavior and 74.5% of them had unsatisfactory reported practice about perineal care. Conclusion: Visually impaired female student had unsatisfactory knowledge about menstrual hygiene and negative genital hygiene behavior. Also, they had unsatisfactory score of reported practice about perineal care. Recommendation: Training and educational program about menstrual hygiene should be provided for visually impaired female students.