Adolescent females are susceptible to polycystic ovarian syndrome, screening and education are crucial steps in managing PCOs. Aim: To assess the prevalence of PCOs among Students at Minia university dorms, evaluate the effect of health education program on their knowledge about PCOs and provide a management plan for confirmed cases. Methods: A cross-sectional research design with intervention was utilized. Setting: The research was conducted in Minia University dorms for female. Sampling: A purposive sample was used; 1083 female student were recruited according to inclusion and exclusion criteria. Tools: Four tools were used, 1st tool: personal data assessment tool: socio-demographic data and menstrual history; 2nd tool: diagnostic criteria for PCOs: risk factors assessment questionnaire, modified Ferriman–Gallwey score for hirsutism, and Rotterdam criteria 2003; 3rd tool: knowledge assessment tool about PCOs; and 4th tool: management plan assessment tool. Results: It showed that 6.7 % of students were diagnosed with PCOs, and 8.8 % of them were risky. Additionally, 8.3% of them had inadequate information about PCOs in the posttest, in comparison to 72.5% in the pretest. Also, there were significant improvements in all management interventions items and clinical features of PCOs for confirmed cases after educational program and follow-up. Conclusion: The prevalence of PCOs among Students at Minia university dorms was 6.7%, the total knowledge of students about PCOS was improved after educational intervention, and the clinical features of confirmed cases showed improvement after following management intervention. Recommendation: Conducting more screening programs among adolescents regarding PCOs in different localities for early detection and management to decrease the long-term health consequences linked to PCOs.