Introduction: The high turnover rate among newly graduated nurses leads to an increased nursing shortage, wastage of nursing education resources, and financial costs for hospitals. Many new nurses choose to leave the nursing profession within their first year of practice, this due to transition shock. Aim: Determine the relationships between transition shock, resilience, and professional quality of life among newly graduated nurses. Study design: a descriptive-correlational research design was used. Setting: The study was conducted at Assiut University Hospitals, which include Main, Pediatric, Women's Health, Urology and Nephrology, Neurology and Psychiatry, EL-Rajhi-Liver, and Cardiology). Subject and Method: A convenient sample of 256 newly graduated nurses in their first year of employment at the mentioned hospitals participated in the study. The data was gathered using selfadministered questionnaires, which encompassed personal characteristics, a transition shock scale, a resilience scale, and a professional quality of life scale. Results: There were a statistically significant relationship between transition shock, resilience, and professional quality of life. Conclusion: There were a positive correlation between resilience and professional quality of life and a negative correlation between transition shock and professional quality of life. Recommendations: Newly graduated nurses should adopt self-care practices like spending time with loved ones, engaging in exercise and meditation, taking restful breaks, and prioritizing relaxation. They need to actively seek support and maintain a healthy work/life balance to prevent or recover from the challenges of transitioning into their professional roles. Additionally, nurse managers should offer facilitated debriefing and clinical supervision sessions for all newly graduated nurses.